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This in silico approach to biology has helped to reshape the modern biological sciences. They help to manage the vast and increasing amount of biological data and continue to play an integral role in the discovery of new biological relationships. Preface Computers have become essential an component of modern biology. Series: Methods in molecular biology (Totowa, N.J.) v. Internet (Computer network) 3.World Wide Web (Informationretrievalsystems)4.Molecular biology-Studyandteaching. Molecular biology-Computer network resources. Library of Congress Cataloging-in-PublicationData Bioinformatics methods and protocols/ edited by Stephen Misener and Stephen A. a separate system of payment has been arranged and is acceptable to Humana Press Inc.

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For those organizations that have been granted a photocopy license from the CCC. For additional copies, pricing for bulk purchases, andor information about other Humana titles, contact Humana at the above addressor at any of the following numbers: Tel: 97 Fax: 97 E-mail:, or visit our Website at Photocopy Authorization Policy: Authorization to photocopy items for internal or personaluse, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $10.00 per copy, plusUS $00.25 per page, is paid directly to the Copyright Clearance Center222 at Rosewood Drive, Danvers, MA 0 1923. ANSI 239.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. This publication is printedon acid-free paper. All authored papers, comments, opinions, conclusions, or recommendations are those of the authorfs), andĭo not necessarily reflect the views of the publisher. Methods in Molecular Biologyy is a trademark of The Humana Press Inc. No part of this book may be reproduced, storedin a retrieval system,or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. Krawetz Wayne State University, Detroit, MIĩ99 Riverview Drive, Suite 208 Totowa, New Jersey 07512 All rights reserved. Stephen Misener Queen 'S University, Kingston, Ontario, Canada Bioinformatics Methods and Protocols Edited by